What is Hashimoto's Disease?

Hashimoto's thyroiditis is an autoimmune condition where your immune system mistakenly attacks your thyroid gland. This occurs when elevated autoantibodies… primarily thyroid peroxidase (TPO) and thyroglobulin antibodies… target thyroid tissue, potentially leading to reduced thyroid function and the symptoms associated with hypothyroidism.

Research shows that 95% of all hypothyroidism cases are actually Hashimoto's, the autoimmune form of hypothyroidism, making it far more common than previously recognized. Functional medicine experts estimate that up to 90% of all thyroid cases are autoimmune in nature, highlighting the critical importance of addressing the underlying immune dysfunction rather than just replacing thyroid hormones.

Subclinical vs. Clinical Hashimoto's

Subclinical Hashimoto's presents with elevated thyroid antibodies but normal thyroid hormone levels (TSH, T3, T4). Any level of antibodies indicates the beginning stages of Hashimoto's. You may or may not experience symptoms at this stage, making it a critical time for intervention before progression to overt hypothyroidism.

Clinical Hashimoto's involves elevated antibodies alongside abnormal thyroid function tests, typically showing elevated TSH and reduced T3/T4 levels. The National Academy of Clinical Biochemists states 95% of people without thyroid dysfunction have TSH levels below 2.5 mIU/L, yet many practitioners still use outdated reference ranges up to 4.5 mIU/L. In Functional Medicine, many labs, including TSH, T3 and T4, are analyzed in a narrow reference range to achieve optimal patient outcomes and address patient symptoms. Symptoms often include fatigue, weight gain, brain fog, hair loss, cold intolerance, and mood changes.

Who's at Risk?

Three key factors contribute to Hashimoto's development:

Genetics: Family history of autoimmune conditions increases susceptibility, but genetics alone don't determine destiny.

Triggers: Various stressors can activate the autoimmune response in genetically predisposed individuals, including:

• Infections (viral, bacterial, parasitic) - Research shows 36% of autoimmune thyroid patients had evidence of recent infections
• Emotional trauma and chronic stress
• Hormonal changes (pregnancy, menopause, puberty)
• Environmental toxins (mold exposure, heavy metals, chemicals)
• Nutrient deficiencies (particularly selenium, vitamin D, iron, and zinc)
• Sleep disruption
• Certain medications
• Excess iodine intake (can worsen Hashimoto's in susceptible individuals)

Be aware of your daily exposures. For example, artificial sweeteners like aspartame, sucralose, and saccharine may trigger Hashimoto's through their negative effects on the gut microbiome, and simply eliminating these may help reverse the condition in some cases.

Gut Permeability: Often called "leaky gut," this condition occurs when the intestinal lining becomes damaged, creating gaps between cells. This allows undigested food particles, toxins, and bacteria to pass through the intestinal wall into the bloodstream. The immune system recognizes these as foreign invaders and mounts an inflammatory response. Through molecular mimicry, the immune system may then mistakenly attack thyroid tissue that resembles these foreign substances.

Research reveals that patients with autoimmune thyroid diseases have altered intestinal mucosal morphology and impaired intestinal permeability. Research also demonstrates that hypothyroidism is associated with small intestinal bacterial overgrowth (SIBO), creating a vicious cycle of gut dysfunction and thyroid problems. For more information about SIBO, please read “Understanding SIBO and the Low FODMAP Diet: A Comprehensive Guide.”

The Gut-Thyroid Connection

Your gut houses 70% of your immune system and produces neurotransmitters that affect mood and metabolism. When gut health is compromised, it creates systemic inflammation that can trigger or worsen autoimmune conditions. The gut-thyroid axis demonstrates how intestinal health directly impacts thyroid function through immune regulation and nutrient absorption.

Gut dysbiosis and intestinal autoimmune diseases occur concurrently with autoimmune thyroid diseases. A 2020 clinical trial found that synbiotic supplementation (combining pre and probiotics) significantly decreased TSH levels, levothyroxine dose requirements, and fatigue scores in hypothyroid patients compared to placebo, highlighting the therapeutic potential of gut microbiome optimization.

Healing Hashimoto's: A Root-Cause Approach

Food as Medicine

Thyroid-Supporting Foods: Focus on selenium-rich foods (Brazil nuts, sardines), iodine from sea vegetables, zinc from pumpkin seeds, and anti-inflammatory omega-3 fatty acids. With a Hashimoto’s diagnosis, it is crucial to maintain optimal vitamin D levels, as studies show vitamin D deficiency correction can reduce thyroid antibodies and improve TSH levels.

Foods to Avoid:

Gluten: Research consistently shows the connection between gluten, zonulin production, and autoimmunity. The Institute for Functional Medicine strongly recommends gluten elimination due to its role in increasing intestinal permeability

Nightshades: (tomatoes, peppers, eggplant, potatoes): Contain alkaloids that may increase intestinal permeability and inflammation in sensitive individuals

Cruciferous Vegetables: (broccoli, cauliflower, kale): Contain goitrogens that can interfere with thyroid hormone production when consumed raw in large quantities

Artificial Sweeteners: These can disrupt the gut microbiome and potentially trigger autoimmune responses

Many patients will have success with individualized nutrition approaches, often utilizing nutrigenomics testing to understand personal food sensitivities and optimal dietary patterns. Approximately 90% of hypothyroid patients will have insulin resistance - this emphasizes the critical connection between blood sugar regulation and thyroid function.

Gut Healing Protocol: The 5R Approach

Remove: Eliminate inflammatory foods, pathogens, and toxins that damage the gut lining. This includes processed foods, sugar, gluten, and potential food sensitivities.

Replace: Restore digestive capacity with digestive enzymes, hydrochloric acid, and bile acids to properly break down food and absorb nutrients.

Reinoculate: Replenish beneficial bacteria through targeted probiotics, prebiotics, and fermented foods to restore healthy gut microbiome balance.

Repair: Heal the intestinal lining using nutrients like L-glutamine, zinc, omega-3 fatty acids, and compounds like slippery elm and marshmallow root.

Rebalance: Address lifestyle factors including stress management, sleep optimization, and regular movement to maintain long-term gut health.

Comprehensive Stress Management

Chronic stress disrupts the hypothalamic-pituitary-adrenal (HPA) axis, elevating cortisol levels that suppress thyroid function and promote systemic inflammation. Cortisol interferes directly with thyroid hormone production and can lead to adrenal fatigue, creating chronic inflammation and immune upregulation.

Effective stress management includes:

Mind-Body Practices: Meditation, deep breathing exercises, yoga, tai chi, and progressive muscle relaxation to activate the parasympathetic nervous system.

Sleep Optimization: Prioritize 7-9 hours of quality sleep, maintain consistent sleep schedules, and create a calming bedtime routine. Poor sleep is both a trigger and consequence of thyroid dysfunction.

Adaptogenic Support: Herbs like ashwagandha, rhodiola, and holy basil help the body adapt to stress and support adrenal function. These have been shown to help restore adrenal health, and can thus improve thyroid function.

Movement: Regular, moderate exercise reduces inflammation and supports mood, but avoid overtraining which can increase stress hormones and worsen thyroid function.

Community and Support: Maintain social connections and consider counseling or therapy to address emotional stressors and develop coping strategies. Mental and emotional trauma have been identified as common predisposing factors for developing autoimmunity.

Address Triggers

Identify and resolve underlying triggers such as chronic infections, heavy metal toxicity, or ongoing stressors that may be perpetuating the autoimmune response. Functional medicine practitioners utilize comprehensive testing including pathogen-associated immune reactivity screens and toxin panels to identify specific triggers.

Infections: including bacterial, parasitic, fungal, and yeast—are associated with virtually every autoimmune condition, particularly affecting gut microbiome integrity where 70% of immune function originates. Environmental exposures like mold toxicity, often overlooked by conventional medicine, have been shown to significantly impact autoimmune thyroid disease.

The Role of Thyroid Medication

While thyroid hormone replacement may be necessary for some patients, it's not always required, especially in subclinical cases. The goal is to address root causes while supporting optimal thyroid function naturally.

At Beach  Cities Wellness, we advocate for appropriate thyroid hormone replacement when indicated. Some patients will still need thyroid hormone medication even with incorporating lifestyle interventions while simultaneously addressing root causes. We emphasizes the importance of comprehensive thyroid testing beyond just TSH, including Free T3, Free T4, Reverse T3, and antibodies.

It is important to understand that in autoimmune Hashimoto’s disease, the thyroid is not at fault - it is a casualty of the immune system, making immune system rebalancing the primary therapeutic target. Your healthcare provider will create a personalized treatment plan based on your specific presentation, symptoms, and comprehensive lab values.

Moving Forward

Hashimoto's is a complex condition requiring a comprehensive approach that addresses diet, gut health, stress, and underlying triggers. Leading functional medicine experts consistently demonstrate that addressing root causes can lead to significant symptom improvement and, in many cases, antibody reduction and remission.

Functional medicine provides a method for rebalancing the body's underlying physiological systems, allowing the body's inherent healing mechanisms to address autoimmune conditions naturally. With proper guidance and commitment to evidence-based lifestyle interventions, many people can significantly improve their symptoms and quality of life while potentially reducing their need for medication.

Work with a qualified functional medicine practitioner to develop a personalized protocol tailored to your unique needs and health history.

References

1. Institute for Functional Medicine. Restoring Thyroid Hormone Balance. Available at: https://www.ifm.org/articles/balancing-thyroid-hormones-naturally

2. Maren C. A Functional Medicine Approach to Hashimoto's Thyroiditis and Hypothyroidism. Dr. Christine Maren. 2025.

3. Caplan Health Institute. Reverse Hashimoto's Disease by Addressing These Nine Underlying Triggers: A Functional Medicine Approach. March 2022.

4. Rupa Health. A Functional Medicine Hashimoto Treatment Protocol: Testing, Supplements, and Nutrition. January 2025.

5. Root Functional Medicine. Hashimoto's Functional Medicine. 2025.

6. Hornaman A. The Thyroid Fixer Podcast. Available at: https://dramie.com

7. Hornaman A. Fixing Thyroid Problems. Functional Medicine Coaching Academy. February 2025.

8. Hornaman A. The Root Causes of Hashimoto's, Testosterone, Hormone Replacement Therapy. The Energy Blueprint. December 2022.

9. Cole W. Thyroid Health. Dr. Will Cole. Available at: https://drwillcole.com/thyroid-health/

10. Cole W. Your Functional Medicine Guide To Underlying Thyroid Dysfunctions + How To Heal. October 2024.

11. Cole W. Guide To Thyroid Support Supplements & Diet. May 2025.

12. Cole W. Hypothyroidism. Dr. Will Cole. May 2020.

13. American Academy of Anti-Aging Medicine (A4M). Conference Educational Programs. 2013.

14. Hu X, Chen Y, Shen Y, et al. Global prevalence and epidemiological trends of Hashimoto's thyroiditis in adults: a systematic review and meta-analysis. Front Public Health. 2022;10:1020709.

15. Wyne KL, Nair L, Schneiderman CP, et al. Hypothyroidism prevalence in the United States: a retrospective study combining National Health and Nutrition Examination Survey and claims data, 2009-2019. J Endocr Soc. 2022;7(1):bvac172.

16. American Thyroid Association. Hashimoto's Thyroiditis. Available at: https://www.thyroid.org/hashimotos-thyroiditis/

17. Cayres LCF, de Sá LBP, Cruz TF, et al. Detection of alterations in the gut microbiota and intestinal permeability in patients with Hashimoto thyroiditis. Front Immunol. 2021;12:579140.

18. Patil AD. Link between hypothyroidism and small intestinal bacterial overgrowth. Indian J Endocrinol Metab. 2014;18(3):307-309.

19. Mori K, Nakagawa Y, Ozaki H. Does the gut microbiota trigger Hashimoto's thyroiditis? Discov Med. 2012;14(78):321-326.

20. Benvenga S, Feldt-Rasmussen U, Bonofiglio D, Asamoah E. Nutraceutical supplements in the thyroid setting: health benefits beyond basic nutrition. Nutrients. 2019;11(9):2214.

Optimal health requires addressing the body's foundational structures. Collagen, comprising approximately 30% of our total body protein, serves as the primary building block for skin, bones, joints, and connective tissues. However, after age 20, we lose about 1% of our collagen production annually… a decline that accelerates dramatically during menopause.

 What Makes Whole Body Collagen  Superior

Designs for Health's Whole Body Collagen stands apart from generic collagen supplements through its unique formulation of three clinically-studied, patented collagen peptides:

FORTIBONE® - For Strong Bones

FORTIBONE® is specifically developed to promote bone health by stimulating bone cells to increase the synthesis of bone components such as collagen. These specific peptides have a 'signaling effect' on osteoblasts to counterbalance collagen degradation in the extracellular bone matrix.

VERISOL® - Skin & Beauty Support

VERISOL® consists of a special patented composition of collagen peptides that are optimized to influence the skin's collagen metabolism directly from the inside.

FORTIGEL® - Joint & Cartilage Health

FORTIGEL® is an innovative ingredient for the regeneration of joint cartilage, with collagenous protein making up nearly 70% of cartilage mass.

The Research Behind FORTIBONE®

Groundbreaking Clinical Studies

Major Clinical Trial Results: A randomized, double-blind, placebo-controlled study of 180 postmenopausal women with reduced bone mass showed that daily intake of 5g FORTIBONE® over 12 months resulted in significant improvements in bone mineral density in both the spine and femoral neck... EVEN WITHOUT weight-bearing exercise. Highlighting this aspect of this study is not meant to discourage your weight lifting, more so to encourage your exercise! 

If the study participants had such good results without weight-bearing exercise, we would expect even more bone remineralization with the incorporation of resistance training alongside FORTIBONE supplementation.

Long-term Follow-up Study: A 4-year follow-up observation of 31 postmenopausal women showed that supplementation with specific bioactive collagen peptides led to a clinically relevant increase in BMD in the spine, with steady improvements maintained over the extended period.

Additional studies also report that patients have self-reported improvements in bone density scans and reduced joint pain.

Why Whole Body Collagen Outperforms Generic Options

1. Targeted Peptide Profiles

Unlike generic collagen, Whole Body Collagen contains 12.5g of specific collagen peptides from FORTIGEL®, VERISOL®, and FORTIBONE®—each with distinct molecular weights and amino acid profiles optimized for specific tissues.

2. Clinical Dosing

The formulation provides therapeutic doses based on published research, not arbitrary amounts found in many commercial products.

3. Superior Bioavailability

GELITA® Collagen Peptides are rapidly absorbed by the body and remain stable even when tested for degradation in cooking. Enjoy hot/cold drinks and even in your baking!

4. Purity & Quality

The product is Non-GMO, gluten-free, dairy-free, and contains no additives—sourced from grass-fed, pasture-raised bovine collagen.

Who Would Benefit From Collagen?

The short answer is everyone. Let’s go through specific conditions that would benefit:

• Joint health and mobility
• Skin elasticity and hydration
• Muscle strength maintenance
• Gut health
• Postmenopausal women
• Patients with osteopenia or osteoporosis
• Active individuals seeking bone density maintenance

The Bottom Line

Whole Body Collagen by Designs for Health represents the gold standard in collagen supplementation, combining three clinically-validated peptide types in therapeutic doses. For practitioners seeking evidence-based solutions for connective tissue health, this formulation offers unparalleled support backed by robust clinical research.

As with any supplement protocol, consult with your healthcare practitioner before beginning, especially if you have existing medical conditions or are taking medications.

* To order your bottle of Whole Body Collagen, call the office at (949)478-2521 

As we age, our skin undergoes profound changes that reflect the complex interplay between hormones, cellular metabolism, and environmental factors. While conventional skincare focuses on surface-level treatments, functional medicine takes a deeper approach by addressing the root causes of skin aging. One promising intervention gaining attention is topical estriol... a gentle yet effective hormone therapy that can rejuvenate facial skin without systemic hormonal disruption.

Understanding Estriol: The Gentle Estrogen

Estriol is one of three primary estrogens produced naturally by the human body, alongside estradiol and estrone. However, estriol stands apart as the mildest and most selective of the three estrogens, making it uniquely suited for topical applications.

How Estriol Differs from Other Estrogens:

Estradiol (E2) is the most potent estrogen, primarily produced by the ovaries during reproductive years. It has strong binding affinity to estrogen receptors and exerts powerful systemic effects throughout the body. While effective, its potency can make it less suitable for localized skin treatments.

Estrone (E1) is the predominant estrogen after menopause, formed primarily in fat tissue through the conversion of androgens. It has moderate potency and can be converted to estradiol in tissues, potentially causing unwanted systemic effects.

Estriol (E3) is the weakest of the three estrogens, with approximately 1/10th the potency of estradiol. It's produced in large quantities during pregnancy and has a unique property: it can provide beneficial estrogenic effects in some tissues while having minimal impact on others.

The Topical Advantage: Localized Benefits Without Systemic Impact

When applied topically to facial skin, estriol offers a significant advantage over oral or transdermal hormone therapy. The molecular structure and application method ensure that estriol remains primarily localized to the treatment area, with minimal systemic absorption.

This localized action means that topical estriol can provide targeted benefits to facial skin without significantly altering overall hormone levels or affecting other body systems. This makes it an attractive option for individuals seeking skin rejuvenation benefits without the concerns associated with systemic hormone replacement therapy.

The Science of Estriol and Skin Health

Research has demonstrated that estrogen receptors are abundant in facial skin, particularly in the dermis and epidermis. As we age and hormone levels decline, these receptors become less activated, leading to visible signs of aging. Topical estriol can help restore this activation locally, providing several key benefits:

Younger-Looking Skin Through Cellular Renewal

Estriol stimulates cellular turnover and promotes the regeneration of skin cells. This process helps shed damaged surface cells while encouraging the growth of healthy, new cells underneath. The result is skin that appears more youthful, with improved texture and a natural glow that comes from enhanced cellular vitality.

Enhanced Elasticity and Plumping Effects

One of the most noticeable benefits of topical estriol is its ability to improve skin elasticity and create a plumping effect. Estriol supports the skin's natural ability to maintain its structure by promoting the production of elastin fibers and supporting the dermal matrix. This leads to skin that feels firmer and more resilient, with a reduction in the appearance of fine lines and wrinkles.

Increased Collagen Production

Collagen is the primary structural protein in skin, providing strength, structure, and elasticity. Estriol stimulates fibroblasts—the cells responsible for collagen production—leading to increased synthesis of both type I and type III collagen. This boost in collagen production helps restore the skin's supportive framework, reducing the appearance of wrinkles and improving overall skin thickness and quality.

Superior Skin Hydration

Estriol enhances the skin's natural barrier function and promotes the production of hyaluronic acid and other moisture-binding compounds. This improved hydration capacity helps the skin retain moisture more effectively, leading to a plumper, more supple appearance and reduced signs of dehydration-related aging.

The Prescription Advantage: Personalized Treatment

Unlike over-the-counter skincare products, topical estriol requires a prescription from a qualified healthcare provider. This requirement ensures that the treatment is appropriate for each individual and allows for personalized dosing and formulation.

A knowledgeable practitioner can assess factors such as hormone levels, skin condition, age, and individual health history to determine the optimal concentration and application protocol. This personalized approach maximizes benefits while minimizing any potential risks or side effects.

Synergistic Compounding: Enhanced Benefits with Vitamin C and Hyaluronic Acid

The true power of topical estriol emerges when it's expertly compounded with complementary ingredients like vitamin C and hyaluronic acid. This combination creates a synergistic effect that amplifies the benefits of each individual component.

Vitamin C: The Antioxidant Powerhouse

Vitamin C is a potent antioxidant that provides multiple benefits for skin health:

• Collagen synthesis support: Vitamin C is essential for the hydroxylation of proline and lysine, amino acids crucial for stable collagen formation
• Antioxidant protection: It neutralizes free radicals that can damage skin cells and accelerate aging
• Melanin regulation: Vitamin C helps inhibit excessive melanin production, leading to more even skin tone
• Cellular repair: It supports the skin's natural repair processes and promotes healing

Hyaluronic Acid: The Ultimate Hydrator

Hyaluronic acid is a naturally occurring substance that can hold up to 1,000 times its weight in water:

• Intense hydration: It draws moisture from the environment and deeper skin layers to the surface
• Plumping effects: The increased hydration creates a visible plumping effect that reduces the appearance of fine lines
• Skin barrier support: It helps maintain the skin's protective barrier function
• Healing acceleration: Hyaluronic acid promotes wound healing and tissue repair

The Triple Synergy: Estriol, Vitamin C, and Hyaluronic Acid

When these three ingredients are combined in a professionally compounded formulation, they create a powerful anti-aging treatment that addresses multiple aspects of skin health simultaneously:

Enhanced Collagen Production: Estriol stimulates fibroblast activity while vitamin C provides the necessary cofactor for collagen synthesis, resulting in more robust collagen production than either ingredient alone.

Superior Hydration: Estriol improves the skin's natural moisture retention while hyaluronic acid provides immediate and long-lasting hydration, creating optimally hydrated skin that appears plump and youthful.

Comprehensive Protection: The antioxidant properties of vitamin C protect against environmental damage while estriol supports cellular repair and regeneration, creating a protective and restorative environment for the skin.

Improved Texture and Tone: The combination addresses both structural changes (through collagen support) and surface irregularities (through cellular renewal and hydration), resulting in smoother, more even-toned skin.

Implementing Topical Estriol in Your Anti-Aging Protocol

Topical estriol represents a sophisticated approach to facial rejuvenation that addresses the hormonal component of skin aging. By working with a qualified healthcare provider, you can determine whether this treatment is appropriate for your individual needs and health profile.

The key to success with topical estriol lies in proper assessment, personalized formulation, and consistent application as part of a comprehensive anti-aging strategy. When combined with other evidence-based treatments and lifestyle modifications, topical estriol can be a powerful tool in maintaining youthful, healthy skin.

As with any medical treatment, it's essential to work with a healthcare provider who understands both the benefits and potential considerations of hormone-based skincare. Through careful evaluation and monitoring, topical estriol can provide significant benefits for those seeking to address the hormonal aspects of skin aging in a targeted, effective manner.

Looking for More Tips for Comprehensive Skin Health?

While topical estriol offers powerful localized benefits, optimal skin health requires a holistic approach that addresses multiple factors contributing to aging and skin quality. Consider these additional strategies to maximize your skin health journey:

Bioidentical Hormone Therapy

For women navigating perimenopause and menopause, bioidentical hormone replacement therapy (BHRT) can provide comprehensive benefits for skin quality, texture, and anti-aging. Systemic hormone therapy addresses the overall decline in estrogen, progesterone, and other hormones that significantly impact skin health throughout the body. While topical estriol serves as a high-powered tool for targeted facial rejuvenation, BHRT can support skin health from the inside out, working synergistically with topical treatments for optimal results.

Foundational Nutritional Support

Hydration: Drinking adequate water is fundamental to skin health. Proper hydration supports cellular function, nutrient transport, and toxin elimination while maintaining skin plumpness and elasticity from within.

Protein Intake: Adequate protein consumption is essential for collagen synthesis and cellular repair. Aim for high-quality protein sources that provide the amino acids necessary for skin structure and regeneration.

Phytonutrient-Rich Diet: A nutritious whole foods diet rich in phytonutrients provides the antioxidants, vitamins, and minerals necessary for skin protection and repair. Colorful fruits and vegetables, healthy fats, and nutrient-dense foods support skin health at the cellular level.

Collagen Supplementation: High-quality collagen supplements can provide the building blocks necessary for skin structure and may support the body's natural collagen production processes.

Personalized Genetic Testing for Skin Health

Designs for Beauty Genetic Testing: Understanding your unique genetic makeup can revolutionize your approach to skincare. The Designs for Beauty genetic test analyzes specific genes that influence skin health, aging patterns, and treatment responses. This comprehensive genetic analysis examines factors such as:

• Collagen production and breakdown patterns
• Antioxidant capacity and free radical protection
• Inflammation response and sensitivity
• Glycation susceptibility (sugar damage to skin)
• UV sensitivity and DNA repair mechanisms
• Detoxification pathways affecting skin health

By understanding your genetic predispositions, you and your healthcare provider can develop a truly personalized skincare protocol. For example, if your genetic profile shows reduced antioxidant capacity, you might benefit from higher concentrations of vitamin C or additional antioxidant support. If you have genetic variants affecting collagen production, treatments like topical estriol, microneedling, or specific peptide therapies might be prioritized in your protocol.

This genetic insight allows for precision medicine approaches to skincare, helping you invest in treatments and products that are most likely to benefit your unique genetic profile while avoiding those that may be less effective for your specific needs.

Advanced Aesthetic Treatments

Microneedling with PRP or PRF: Microneedling combined with platelet-rich plasma (PRP) or platelet-rich fibrin matrix (PRFM) harnesses the body's natural healing factors to promote collagen production, improve skin texture, and enhance overall skin quality.

Topical Rapamycin: This innovative anti-aging compound works at the cellular level to promote longevity pathways and may help slow the aging process in skin cells.

Topical Exosomes: These cutting-edge regenerative medicine tools contain growth factors and signaling molecules that can promote cellular repair and regeneration, offering another frontier in advanced skincare.

The Integrative Approach

The most effective anti-aging strategies combine multiple modalities to address skin health from various angles. Topical estriol serves as a powerful component in this comprehensive approach, providing targeted hormonal support while other treatments and lifestyle factors support overall skin health and longevity.

Working with a knowledgeable functional medicine practitioner can help you develop a personalized protocol that integrates these various approaches based on your individual needs, health status, and aesthetic goals.

This information is for educational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider before beginning any new treatment protocol.